So much can influence it. For me, on Elvanse though, what I found is lack of sleep and a starting viral infection.
Reducing caffeine also helps. It adds up with the prescription stims, and they help more.
My son once had a complete stop of any effect a while ago. Doc couldn’t figure it out for sure. My theory: He took it on mashed apples with no water. Water might be crucial. It does say so in the instructions, but hard to say what exactly happens when it’s too little.
So many possible reasons …



Exactly - my “autistic unload” is not really that interesting, and it’s hard to be my friend. All while I am having a hard time to understand and process their situation and FEEL something about it. Got to keep myself off calling people just because they expressed interest in something I did or said at some point. If I called the last 2 or 3 times, it’s time for them to make a move.
Pair that with various coping characteristics developed through decades, and I can be an annoying friend at times.