Yes, in my experience the only people in your life who really struggle are people who have their own issues (i.e. it never actually seems to be about you or your transition exactly) e.g. people who are closeted and who experience pain when reminded of their issues when they see you.

Usually even a bigoted religious person isn’t directly mean to you, it seems like the Christians generally reiterate how much they love you and so on (but they don’t want to talk too much about gender). In fact, I don’t find anyone wanting to talk about gender IRL, lol. Anyway, it’s hard to tell how it will go - I think it’s also different if you’re a minor living at your parents’ house compared to an independent adult. It also depends on who is in your life, and how they felt about you before you transitioned.

Either way, transitioning is like taking medication as a diabetic or someone with hypothyroidism - it really is life-saving and necessary.