For me, it would be GLaDOS.
Portal 2 spoiler
She deleted the one remaining human part of herself because it was just too much to deal with. She releases you at the end of Portal 2 as a path of least resistance measure because “killing you is hard.”
What about you, what is your favorite media villain?


I am looking for the like and subscribe buttons for this long-form video essay dissecting Star Trek antagonists, but I don’t see any. 😉